The St. Rose of Lima Parish Church, commonly known as Gamu Church, is one of the long-established Catholic churches in Isabela, located in the municipality of Gamu. Its origins date back to the Spanish colonial period, when Dominican missionaries organized missions across the Cagayan Valley. The church was constructed around 1750 by Martin Fernández, a priest who also laid out the town planning of Gamu, making it one of the early organized settlements in the area.

The church is dedicated to Saint Rose of Lima, the first canonized saint of the Americas. She is recognized as the patron saint of embroidery, gardening, and the cultivation of blooming flowers. The dedication reflects the influence of Spanish Catholic traditions introduced during the colonial period, and the parish has remained a central place of worship for the community.

Architecturally, the church follows a Baroque style, with its most distinct feature being the facade’s pointed towers. Like many churches in the region, it was originally built using local materials such as brick and stone. Over time, the structure underwent repairs and renovations due to exposure to natural elements such as typhoons and earthquakes. Despite these changes, it retains key elements of its historical design.

In 2019, the National Museum of the Philippines declared the church as a National Cultural Property, recognizing its historical and cultural significance.